Mibelle Biochemistry is introducing a biologically active hepta-peptide that stimulates the skin’s own self-defense mechanisms against oxidative stress at the cellular level.
Our cells respond to oxidative stress by activating the transcription factor Nrf2. This is a master switch in the cellular self-protection system that leads to an increased synthesis of cell protecting enzymes in order to fight oxidants, free radicals and toxins.
However, this self-protection system of the skin is unable to cope with an excess of stress factors and it also declines with age.
Normally Nrf2 activity is repressed by the Keap1 protein. Nrf2 only becomes activated when the cells are faced with too much oxidative stress. In response to this, Mibelle Biochemistry has designed a hepta-peptide that is a competitive inhibitor of the Keap1 repression. Consequently, Nrf2 is now constantly present in its active form and arms the skin cells for challenges from any stress caused by oxidants or other reactive chemical species.
In cell culture assays, PerfectionPeptide P7 clearly stimulated the expression of detoxifying enzymes. In ex-vivo experiments and clinical trials the peptide has shown an ability to significantly protect the skin from oxidative stress at the cellular level:
PerfectionPeptide P7 significantly reduces
- DNA damage
- UV-induced formation of sunburn cells
- Depletion of Langerhans
PerfectionPeptide P7 provides a unique strategy to fight both environmental and chronological aging.
To ensure the stability and bioavailability of PerfectionPeptide P7 the peptide has been encapsulated into a novel soft sphere carrier system that is based on shea butter.
PerfectionPeptide P7 is much more than an anti-oxidant: it offers a 360° protection from daily stress factors, ROS and toxins. Therefore, it is an ideal active for any daily defense formulation to safeguard both the youthfulness and beauty of your skin.
INCI/CTFA-Declaration
Acetyl sh-Heptapeptide-1 (and) Hydrogenated Lecithin (and) Glycerin (and) Butyrospermum Parkii (Shea) Butter (and) Phenethyl Alcohol (and) Ethylhexylglycerin (and) Aqua/Water
About Mibelle Biochemistry
Inspired by nature – Realized by science
Mibelle Biochemistry, a Swiss company, is specialized in the research and development of innovative, high-quality actives for the cosmetic industry. Inspired by nature Mibelle Biochemistry transforms naturally derived compounds into truly functional cosmetic ingredients. Furthermore Mibelle Biochemistry possesses powerful encapsulation technologies that guarantee optimum bioavailability. All products are accompanied by comprehensive technical support and marketing-oriented documentation.