Regaining a youthful look

Eating healthily, working out, and winding down: consumers around the world are increasingly taking a more mindful approach to the way they live their lives. But even with a healthy lifestyle, biology can’t be outsmarted – time takes its toll: our skin loses its firmness, becomes more fragile, and wrinkles creep in; and the dense collagen-rich extracellular matrix network (ECM), which confers strength and mechanical support to the skin, undergoes progressive atrophy.

A powerful peptide blend

Anti-ageing actives are in great demand, yet breakthroughs have remained few and far between. With Replexium1, BASF has achieved a new milestone: in vivo, the blend of Acetyl Tetrapeptide-9 and Acetyl Tetrapeptide-11 (see fig. 1*) visibly reduces wrinkles within three weeks – significantly faster than a peptide benchmark. Additionally, it makes the skin look as firm as skin that is seven years younger. 

The skin-bioavailable synergistic complex of the two tetrapeptides – very small molecules that can achieve a high level of efficacy in low dosages – improves the signs of ageing by targeting the epidermis and dermis as well as the membrane zone that joins them, the dermal-epidermal junction (DEJ) zone. This three-level approach promises rapid and lasting anti-ageing effects. 

Replexium is a preservative-free syrupy liquid, pale yellow to yellow, which is soluble in water and insoluble in oils and fats. It contains 350–650 ppm of Acetyl Tetrapeptide-9 and 525–825 ppm of Acetyl Tetrapeptide-11 with skin-bioavailability agents. At a recommended dose of 2%, this active ingredient is incorporated during final processing below 
40 °C, or at room temperature for cold processing. On request, Replexium is also available as a powder without bioavailability agents under the reference Replexium PW BC10082 with the INCI name Mannitol (and) Acetyl Tetapeptide-11 (and) Acetyl Tetrapeptide-9; dose of use 1%).